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Analysis and PDE Seminar

Title: Informatics and Modeling Platform for Stable Isotope-Resolve Metabolomics



Abstract: Recent advances in stable isotope-resolved metabolomics (SIRM) are enabling orders-of-magnitude increase in the number of observable metabolic traits (a metabolic phenotype) for a given organism or community of organisms.  Analytical experiments that take only a few minutes to perform can detect stable isotope-labeled variants of thousands of metabolites.  Thus, unique metabolic phenotypes may be observable for almost all significant biological states, biological processes, and perturbations.  Currently, the major bottleneck is the lack of data analysis that can properly organize and interpret this mountain of phenotypic data as highly insightful biochemical and biological information for a wide range of biological research applications.  To address this limitation, we are developing bioinformatic, biostatistical, and systems biochemical tools, implemented in an integrated data analysis platform, that will directly model metabolic networks as complex inverse problems that are optimized and verified by experimental metabolomics data.  This integrated data analysis platform will enable a broad application of SIRM from the discovery of specific metabolic phenotypes representing biological states of interest to a mechanism-based understanding of a wide range of biological processes with particular metabolic phenotypes.

Date:
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Location:
745 Patterson Office Tower

Analysis and PDE Seminar

Title:  Some progresses on two-dimensional Riemann problems in gas dynamics

 

Abstract:  Two dimensional Riemann problems for compressible fluid flows assume the simplest piecewise sectorial initial state but provide the most fundamental wave configurations, including the reflection of oblique shocks and vortex-shock interaction etc. In this talk I will show many fascinating pictures, based on 2D Riemann solutions, to disclose the mysteries of compressible fluid world both through analytical tools (in the form of mathematical theorems) and computational techniques (in the form of simulations). The analysis is based on the characteristic decomposition theory we developed recently, while the simulations are obtained using the generalized Riemann problem (GRP) scheme that is equipped with a highly accurate solver in the construction of numerical fluxes by a way of tracking singularities analytically and keeping entropy exactly computed. 

Date:
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Location:
745 Patterson Office Tower
Event Series:

"Davis Bottom: Rare History, Valuable Lives" Premiere

The Kentucky Archaeological Society will host a screening of "Davis Bottom: Rare History, Valuable Lives" at Farish Theater at the Lexington Public Library. In addition to screening the hour-long documentary, viewers will be able to meet some of the sponsors and the program producer. After the documentary, attendees will be able to participate in a discussion about the critical role primary documents played in telling the neighborhood's story.  

For more information about the Davis Bottom Project, click here

Date:
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Location:
Farish Theater, Lexington Public Library, 140 Main St

Analysis and PDE Seminar

Title:  Smoothness of isometries between subRiemannian manifolds

Abstract:  In a joint work with Enrico Le Donne (Jyvaskyla, Finland), we show that the group of isometries (i.e., distance-preserving homeomorphisms) of an equiregular subRiemannian manifold is a finite-dimensional Lie group of smooth transformations. The proof is based on a new PDE argument, in the spirit of harmonic coordinates, establishing that in an arbitrary subRiemannian manifold there exists an open dense subset where all isometries are smooth.

Date:
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Location:
215 White Hall Classroom Building

Analysis and PDE Seminar

Title:  Higher-order analogues of the exterior derivative complex

Abstract:  I will discuss some earlier joint work with E. M. Stein concerning div-curl type inequalities for the exterior derivative operator and its adjoint in Euclidean space R^n. I will then present various higher-order generalizations of the notion of exterior derivative, and discuss some recent div-curl type estimates for such operators. Part of this work is joint with A. Raich.

Date:
-
Location:
745 Patterson Office Tower
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